Infertility Caused by Unexplained Infertility Problems

Infertility Caused by Unexplained Infertility Problems

Infertility diagnosed to be due to unexplained infertility problems is one puzzling answer to receive. Most couples having tried everything find it frustrating to hear an answer that for all intents and purposes seems like a dead end. However, there is more to unexplained infertility than meets the eye, so let us take a closer look at what it really means, and if it is a reason for relief or despair. Claim Your 20 Free Pregnancy Tests – Click Here

Facts of unexplained infertility

First of all, when do we say a couple is infertile? We are only talking about infertility if a couple cannot achieve pregnancy for one year despite frequent, unprotected intercourse especially at the time of ovulation. But what does it mean when we hear that it is “unexplained”?

Well, it only means that the health care provider has no idea what is wrong. They probably tested you for everything under the sun, but all tests returned a negative result, so now they have no idea where else to look. In other words, infertility diagnosis is based on exclusion of potential problems.

It depends on the number of tests that were performed. Naturally, the available technology limits the number of tests that can be performed, but as a rule of thumb infertility is unexplained if: the woman has regular ovulation, no pelvic adhesion, no endometriosis, the fallopian tubes are healthy and open, the man has sufficient sperm count, the sperm are mobile, and the postcoital test is positive.

Based on this standard, 1 out of 10 infertile couples have unexplained infertility problems.

When unexplained infertility is good news

Now let us take a look at the possible causes of unexplained infertility. In most cases however, negative infertility results are good news. Chances are, you have only been unlucky so far. More than 30% of the time, these unlucky couples achieve pregnancy in the upcoming three years. Of course, there can be more subtle causes of unexplained infertility.

High sperm DNA damage

One prominent cause is high sperm DNA damage. Fortunately, there are available medical examinations that can detect this kind of disorder. The test results will return a percentage of damaged sperms: a result below 15% is considered normal, while results higher than 25% mean that there is a lower chance of successful conception even with infertility treatments.

Follicle or fallopian tube problems

On the other hand, there can be other reproductive system malfunctions that cause infertility, but cannot be detected by the above-mentioned set of standard tests. One such abnormality occurs when the fallopian tubes cannot receive the matured egg successfully, therefore the egg never meets the sperm. There is a chance that the woman produces deformed eggs, or that the follicles do not rupture properly to release the matured egg. It remains trapped inside the follicle (Luteinized Unruptured Follicle).

Immunological factors

There are certain immunological factors to be taken into account, such as sometimes the body of the woman may misinterpret the sperms to be hostile organisms, and might kill them, or immobilize them.


Sometimes infections are responsible for infertility, that don’t show up in clinical examinations, but are nevertheless present in the patient’s system, which is why some doctors use antibiotics during therapy.

Sperm problems

The problem can be with the man’s sperms: occasionally it is too weak to penetrate the egg. This possibility can be easily excluded by performing a donor test. If the donor’s sperm is able to penetrate the woman’s egg, then the problem is definitely with the man’s sperm.

Even the uterine lining can have hardly detectable abnormalities which do not allow the egg to implant. But with multiple vaginal ultrasound tests this problem can be detected. If the uterine lining is too thin, the root cause may be related to smoking, which can prevent blood flow to the uterus.

Points to remember

And last but not least, while scientifically stress cannot cause infertility, strong emotions, especially depression may influence the parts of the brain responsible for hormone balance. It is a always a good idea to ensure a peaceful, stable environment while trying to conceive.

Treatments for infertility

There are several solutions to the above-mentioned problems. While they may seem complex, the solution is often very simple. Most doctors recommend fertility drugs for first-line therapy, such as Clomid.

When undertaking Clomid therapy, make sure to consult your health-care provider as it can have side-effects that severely hinder conception. With intrauterine insemination most of the undetectable problems can be bypassed, and in-vitro fertilization can help with tubal or ovarian abnormalities.

However, in most cases it’s just sheer lack of luck, so not giving up and creating a nourishing, rich emotional environment might just be what the frustrated couple needs in such times of despair. Any infertility treatments can certainly increase your chances of having twins, which can be a blessing in disguise!

ConceiveEasy TTC Kit + 20 FREE Pregnancy Tests

Monica Scott, BS, RN
Monica Scott, BS, RN | ConceiveEasy
Ms. Scott joined ConceiveEasy after working in prenatal obstetrical care for two years in a private practice before being promoted to Director of Nursing. She has a strong interest in women's health with an emphasis on promoting fertility awareness.