Fertility Drugs and Intrauterine Insemination (IUI)

Fertility Drugs and Intrauterine Insemination (IUI)

Fertility drugs and IUI are strongly related when it comes to increasing the chances of women to achieve pregnancy. During a typical intrauterine insemination (IUI) procedure, male sperm is placed directly into the uterus, thus seriously increasing the chances of pregnancy. In most cases doctors recommend fertility drugs in conjunction with IUI, to improve the chances of success. These drugs are meant to stimulate the ovaries and make them produce more eggs and boost the odds of having a baby. Claim Your 20 Free Pregnancy Tests – Click Here

IUI with or without fertility drugs?

It has been established that IUI works both with and without fertility drugs, so the question is: How does one decide when to use them? It is an important decision, which should be made by the fertility specialist, who has to take into consideration various factors.

The use of fertility drugs alongside IUI is strongly related to the causes behind the infertility, especially the age of the patient. When the infertility is age-related or has unexplained causes, the drugs help the woman produce a larger number of eggs for fertilization.

They also help doctors to better synchronize the ovulation with IUI. Sometimes the woman ovulates normally and the infertility is male related. Low sperm count, sperm morphology or poor sperm mobility are disorders which affect many men. Even in such cases couples are offered fertility medications in addition to IUI.


Super-ovulation is the production of multiple eggs due to fertility drugs. A woman ovulates one egg per cycle. But when fertility drugs are used, woman may produce more than one egg, thus “super ovulating”.

Which fertility drugs?

The IUI procedure is commonly assisted with fertility drugs, such as Clomid or Serophene or clomiphene citrate or with drugs named gonadotropins (hCG, FSH and hMG). Clomid is a fertility booster which has to be taken orally for five days, once the period begins.

It is one of the most commonly drug used with IUI since it has few negative side effects and is relatively cheap in comparison with other fertility drugs. It has 80% success rate in stimulating ovulation. Gonadotropins are fertility drugs with Luteinizing hormone (LH) and Follicle-stimulating hormone (FSH) injected to the patient.

Another fertility enhancer is Human chorionic gonadotropin (hCG), which acts as a trigger and boosts the occurrence of the LH. Overall, doctors consider gonadotropins to be much more aggressive in treatment than Clomid.

Fertility drugs and IUI are the typical combo used by fertility specialists to help women who have encountered difficulties when trying to conceive.

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Dr. Prabha Sahgal, MD
Dr. Prabha Sahgal, MD | ConceiveEasy
Dr. Prabha Sahgal MD, is board certified in obstetrics and gynecology and subspecialty board certified in reproductive endocrinology and infertility. Dr. Sahgal holds a B.S. degree from MIT in molecular biology and currently serves on the ConceiveEasy board of directors.