Clomid or Metformin: Which is Better?

on Oct 12, 2013

by Maureen Stephens, BS, RN

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If you're having trouble ovulating, chances are your doctor has mentioned Clomid or Metformin. Some cases might benefit from adding Clomid to Metformin, or vice versa. There are some cases that Metformin alone is going to be the only option.

All about Clomid

Clomid is the most popular and most commonly used fertility drug on the market today. For women struggling with PCOS or ovulation problems, Clomid is the go-to drug, and is usually the first drug of choice of every fertility doctor. Clomid is given orally and is taken for five days, usually on days 5-9 of a woman’s cycle. Of all the women who take Clomid, about 80 percent will begin to ovulate after taking it, and around 45 percent of those women will become pregnant within six cycles. Clomid has very few side effects, and the side effects that it does have are mild. Claim Your 20 Free Pregnancy Tests – Click Here

All about Metformin

Metformin is a drug that is usually used to treat women with PCOS who are having a hard time getting pregnant. Metformin was not created to treat PCOS. In fact, PCOS is not even on the list of things that Metformin is supposed to treat. What is Metformin designed to treat? Insulin resistance for people with diabetes. Women with PCOS also often have insulin resistance, so Metformin can help treat their insulin resistance, and in turn, can help them resume ovulation. Sometimes, Metformin is also given to women who are resistant to Clomid, or who have suffered with repeated miscarriage.

Which is better?

In Feb 2007, The New England Journal of Medicine published a study titled: “Clomiphene, metformin, or both for infertility in the polycystic ovary syndrome.” The study followed 626 women who were infertile and diagnosed with PCOS and gave some of them Clomid, some of them Metformin and some of them both. Then they studied the live birth rates of all three of the groups. The group who received just the Clomid had a birth rate of 22.5%, the group who received the Metformin had a birth rate of 7.2%. The group who received the combination of the Clomid and the Metformin together had a birth rate of 26.8%. So, by looking at the study, Clomid is the best option for inducing ovulation. Taking both together is also a good option, but Metformin by itself isn’t the best choice.

What to do

Every situation is different, and every case is different. Your doctor will tell you which option is the best for you. Some cases might benefit from adding Clomid to Metformin, or vice versa. There are some cases that Metformin alone is going to be the only option. In other cases, Metformin won’t help, and doctors won’t want to prescribe what isn’t necessary. There is no way to really tell in general which option is the best.

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Clomid or Metformin: Which is Better?, 4.4 out of 5 based on 7 ratings

Ms. Stephens has spent over twenty years in the healthcare world, specializing in obstretical and medical/surgical nursing. She joined ConceiveEasy as she has a strong interest in educating and empowering women and promoting fertility awareness.

  • PJ

    Can you take conceive easy with clomid and metformin?

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  • Yovonda Fuller

    Can you take Metformin and Conceive Easy together?

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  • asteria

    i took metaformin and chlomid together so as to induce fertillty i haveskipped my menstrual date by one day is it a possibility that i might be pregnant or its just change of climate

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  • Kelsey

    I took Metformin on its own as well as a PCOS diet and was having normal periods within a month and pregnant within 6 months, after TTC for 2 years. It definitely is different for everyone!

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