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IVF Failure: Top 4 Reasons When In-Vitro Doesn’t Work

on Sep 22, 2012

by Alyssia Granger

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IVF Failure: Top 4 Reasons When In-Vitro Doesn't Work

The four main reasons that IVF fails are female age, embryo quality, ovarian response, and implantation issues. Find out more about each and what you can do about it.

IVF is a great treatment option for a ton of couples. It can grant people their wish of becoming parents when they didn’t think it was possible. However, the truth of the matter is, that IVF doesn’t always work. At least, not on the first try. There are many couples out there that have to go through more than one cycle of IVF before getting pregnant. The fact of the matter is that IVF is very expensive, not to mention the fact that it is a very stressful process. It can be very hard to accept when your IVF treatment does not work, and it can be very difficult to understand why. Claim Your 20 Free Pregnancy Tests – Click Here

There are a few reasons that your IVF treatment might have failed. The four main reasons that IVF fails are female age, embryo quality, ovarian response, and implantation issues. We are going to explore a little more into each of those reasons and see how they might possibly contribute to IVF failure.

Female Age

As we are very familiar with, your likelihood of getting pregnant as you get older decreases over time. Since each woman is born with a certain number of eggs, as you age, you use those eggs up. Your likelihood of a live birth after IVF is greater the younger that you are. Some studies show that the likelihood of a live birth after IVF for a woman age 35 is around 32 percent, but only 16 percent for a woman who is 40. Of course, this is not a guarantee that IVF won’t work for your particular case.

Embryo Quality

Embryo Quality can be another contributing factor to IVF failure. Some embryos have genetic or chromosomal abnormalities that can make them too weak too work for IVF. Still other embryos don’t have enough cells to survive and are less likely to fertilize. There are quite a few things that can contribute to embryo quality which can eventually lead to IVF failure

Ovarian Response

Sometimes a woman’s ovaries just do not respond properly to the IVF medications that try to get the ovaries to produce multiple eggs. If you already have a reduced number of eggs, are over 37, or have elevated FSH levels, it might be harder for your body to respond properly to IVF medications. In short, if your body listens to the medication and produces more eggs, your IVF is likely to be successful. If it doesn’t, then your chances that the IVF will fail are greater.

Implantation Issues

Implantation issues are probably the most common reason that IVF treatment fails.Most of the time when implantation issues occur, it is simply because the embryo stops growing and through no fault of anyone. If there are polyps or cysts on the ovaries, this can also be a contributing factor to implantation issues. Some research even suggests that chromosomal abnormalities that can cause implantation issues in embryos can be present in as many as 50% of cases!

These are the four most common reasons that IVF treatment fails. Just because you experience a failed IVF attempt doesn’t meant that you should give up trying to get pregnant. That is not the case at all. You do need to reevaluate and make sure that you are happy with your doctor, your clinic and the services that you are receiving before attempting again. Also, talk candidly with your doctor about what he or she thinks might have went wrong and if there is anything that you or your partner can do to help things go smoothly the next time around. The most important thing is to stay positive and don’t give up!

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IVF Failure: Top 4 Reasons When In-Vitro Doesn't Work, 3.3 out of 5 based on 11 ratings

Alyssia is mom to 2 giggley twin girls, Sophia and Emma, and son Hunter. She's a Southern girl, passionate about photography, travel and her husband Josh.

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  • Shwetha

    Hey Anya and Susan, please let me know your FB ID, I would like to connect with you, am going through a trauma as well..

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  • Shwetha

    Hey Anya, please let me know your FB ID, I would like to connect with you, am going through a trauma as well..

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  • Anya

    What is urs? I will add u

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  • Anya

    Hi …do u have fb? Can i add u on my fb

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  • Anya

    Hi what is ur id on fb i will add u

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  • shimpa

    Hi, I am 31 year and have went through the 1st cycle of IVF as diagnosis says bilateral endometriotic ovarian cysts left and right with bilateral tubal adhesion & pelvic adhesion. So my last month i went through IVF cycle but the beta hcg was 27.3. Doc suggest to stop all medicine and wait to get my period. May be she will plan next month. kindly suggest.

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  • pannu dextor

    I could not conceive in my first IVF cycle. Shall I go for second IVF in the very next cycle or wait for sometime?
    What are various reasons for failure of an IVF?

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  • mary

    hai dr,
    i did my egg retrieval on nov. 22 and et on 27 november. checked b hcg on 11 december and found it to be 36mi ul. my doctor was not satisfied with the reading and told to review it on 13 dec. i did it yesterday and found it to be 11. what would have possibly gone wrong?

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  • Paulo

    2days to go till we take the test to see if everything has worked. However wife feels that her period is coming on. We did a test this morning but that was negative. So what are the chances the test will be positive on Wednesday? Thanks paulo

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  • Jennie Rose Manera

    Hi! I’m 38 years old did two IVF implantation with a PGD and was a failure. I had pregnant 4 x normally but since I’m fertile I did tubal ligation and now I’m trying to have a baby boy. I’m just curious why I can’t get pregnant through IVF? And my fiancée has a daughter on his own. We don’t have issue about infertility. Is it because of age? I’m so confused. What do you advice? Do I need to look for a new fertility doctor?

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  • alicia

    I’m 41 did my second ivf transfer the first I got a negative and the second I got a positive but then my numbers was to low so my doc.told me to stop the meds so what should I do. I’ll be 42 in 3months should I try against

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  • Norizza Neri

    Hi…ds is zsa-zsa, 31 years old…i went on IVF started on may 3 this year and ET done on 6th of May.I felt some abdominal cramping like menstrual cramps plus breast tenderness for about 8 days after that cramps was getting lesser until beta hcg test done today on my 11th day post ET and it was less than 1. We came out to this last option to conceive because of my partner’s sperm count. Prior for that My consultant told me that is was perfect I got 7 fertilsed egg, healthy sperm, no problem with the uterus and grade 1 embryo which is good based in the grading system by institution…I AM SO DEPRESSED right now dont know what to do.What is the possible cause of failure of my IVF cycle?

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  • Marie

    I am 29yrs of age. I’ve been to diffrent doctors and after all of them not being able to give me an answer for my infertility. My husband and I agreed to go through IVf. Two weeks after my transfer My blood test came back negative. It sadden me because I did everything the Doctor told me too. Is there something I might be doing wrong that should be done better. I have 2 frozen embryos left and I am scared to retry and it not work again.

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